Table 6.
Artesunate dose | Children < 20 kg | Patients > 20 kg | All patientsa | ||||||
---|---|---|---|---|---|---|---|---|---|
Round 1 N = 195 |
Round 2 N = 253 |
p-value | Round 1 N = 112 |
Round 2 N = 117 |
p-value | Round 1 N = 307 |
Round 2 N = 370 |
p-value | |
n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | ||||
Recommendedb | 107 (54.9) | 166 (65.6) | 0.049 | 69 (61.6) | 93 (79.5) | 0.008 | 176 (57.3) | 259 (70.0) | 0.003 |
Below recommended | 70 (35.9) | 56 (22.1) | 0.008 | 15 (13.4) | 5 (4.3) | 0.017 | 85 (27.7) | 61 (16.7) | 0.005 |
Above recommended | 18 (9.2) | 31 (12.3) | 0.265 | 28 (25.0) | 19 (16.2) | 0.147 | 46 (15.0) | 50 (13.5) | 0.581 |
a31 patients without dose information were excluded
b3 mg/kg for patients < 20 kg; 2.4 mg/kg for patients > 20 kg