Table 1.
Clinical and morphological characteristics of patients with or without chemo-resistance
| Variable | Category | Number(%) | Chemo-sensitive(%) | Chemoresistance(%) | P |
|---|---|---|---|---|---|
| 304 | 252(82.9%) | 52(17.1%) | |||
| Age | < 48 | 129(42.43) | 114(45.24) | 15(28.85) | 0.0294* |
| ≥48 | 175(57.57) | 138(54.76) | 37(71.15) | ||
| Menopausal status | Pre | 161(52.96) | 139(55.16) | 22(42.31) | 0.0909 |
| Post | 143(47.04) | 113(44.84) | 30(57.69) | ||
| Gravidity | < 1 | 35(11.51) | 31(12.3) | 4(7.69) | 0.3431 |
| > = 1 | 269(88.49) | 221(87.7) | 48(92.31) | ||
| Parity | < 1 | 51(16.78) | 46(18.25) | 5(9.62) | 0.1290 |
| > = 1 | 253(83.22) | 206(81.75) | 47(90.38) | ||
| Abdominal pain | No | 210(69.08) | 174(69.05) | 36(69.23) | 0.9016 |
| Yes | 93(30.59) | 77(30.56) | 16(30.77) | ||
| Bloating | No | 243(79.93) | 208(82.54) | 35(67.31) | 0.0125* |
| Yes | 61(20.07) | 44(17.46) | 17(32.69) | ||
| Palpable mass | No | 223(73.36) | 182(72.22) | 41(78.85) | 0.3253 |
| Yes | 81(26.64) | 70(27.78) | 11(21.15) | ||
| Incidental finding | No | 256(84.21) | 208(82.54) | 48(92.31) | 0.0786 |
| Yes | 48(15.79) | 44(17.46) | 4(7.69) | ||
| Irregular menstruation | No | 275(90.46) | 226(89.68) | 49(94.23) | 0.3094 |
| Yes | 29(9.54) | 26(10.32) | 3(5.77) | ||
| Postmenopausal bleeding | No | 285(93.75) | 235(93.25) | 50(96.15) | 0.4316 |
| Yes | 19(6.25) | 17(6.75) | 2(3.85) | ||
| Emaciation | No | 294(96.71) | 248(98.41) | 46(88.46) | 0.0002* |
| Yes | 10(3.29) | 4(1.59) | 6(11.54) | ||
| Abnormal vaginal discharge | No | 302(99.34) | 250(99.21) | 52(100) | 0.5192 |
| Yes | 2(0.66) | 2(0.79) | 0(0) | ||
| Ca125 in normal range(< 35 U/L) | No | 249(81.91) | 199(78.97) | 50(96.15) | 0.0034* |
| Yes | 55(18.09) | 53(21.03) | 2(3.85) | ||
| CA125group | < 90 | 112(36.84) | 104(41.27) | 8(15.38) | 0.0004* |
| ≥90 | 192(63.16) | 148(58.73) | 44(84.62) | ||
| Early or late Stage | FIGO I + II | 185(60.86) | 175(69.44) | 10(19.23) | <.0001* |
| FIGO III + IV | 119(39.14) | 77(30.56) | 42(80.77) | ||
| FIGO stagea | I | 141(46.38) | 136(53.97) | 5(9.62) | <.0001* |
| II | 44(14.47) | 39(15.48) | 5(9.62) | ||
| III | 104(34.21) | 69(27.38) | 35(67.31) | ||
| IV | 15(4.93) | 8(3.17) | 7(13.46) | ||
| Tumor size group | < 7 | 80(26.32) | 66(26.19) | 14(26.92) | 0.9130 |
| ≥7 | 224(73.68) | 186(73.81) | 38(73.08) | ||
| Pathology Grade | G1 | 45(24.19) | 44(28.03) | 1(3.45) | 0.0128* |
| G2 | 59(31.72) | 49(31.21) | 10(34.48) | ||
| G3 | 82(44.09) | 64(40.76) | 18(62.07) | ||
| Pathology type | Endometrioid | 186(61.18) | 157(62.30) | 29(55.77) | 0.435 |
| Clear cell | 118(38.82) | 95(37.70) | 23(44.23) | ||
| Endometriosis | No | 235(77.30) | 188(74.6) | 47(90.38) | 0.0134* |
| Yes | 69(22.70) | 64(25.4) | 5(9.62) | ||
| Side of tumor | Unilateral | 212(69.74) | 183(72.62) | 29(55.77) | 0.0160* |
| Bilateral | 92(30.26) | 69(27.38) | 23(44.23) | ||
| LN metastasis | No | 213(70.07) | 195(77.38) | 18(34.62) | <.0001* |
| Yes | 40(13.16) | 24(9.52) | 16(30.77) | ||
| unclear | 51(16.78) | 33(13.1) | 18(34.62) | ||
| LN dissection | No | 51(16.78) | 33(13.1) | 18(34.62) | 0.0002* |
| Yes | 253(83.22) | 219(86.9) | 34(65.38) | ||
| Residual disease | No | 231(75.99) | 207(82.14) | 24(46.15) | <.0001* |
| Yes | 73(24.01) | 45(17.86) | 28(53.85) | ||
| TH | No | 297(97.7) | 246(97.62) | 51(98.08) | 0.8411 |
| Yes | 7(2.3) | 6(2.38) | 1(1.92) | ||
| Tubal ligation | No | 290(95.39) | 243(96.43) | 47(90.38) | 0.0583 |
| Yes | 14(4.61) | 9(3.57) | 5(9.62) | ||
| Sterilization surgery | No | 283(93.09) | 237(94.05) | 46(88.46) | 0.1481 |
| Yes | 21(6.91) | 15(5.95) | 6(11.54) | ||
| Endometrial disorder | No | 252(82.89) | 208(82.54) | 44(84.62) | 0.7174 |
| Yes | 52(17.11) | 44(17.46) | 8(15.38) | ||
| Variable endometrial disorder | No | 252(82.89) | 207(82.14) | 45(86.54) | 0.7998 |
| EP | 27(8.88) | 23(9.13) | 4(7.69) | ||
| EIN | 22(7.24) | 19(7.54) | 3(5.77) | ||
| EC | 3(0.99) | 3(1.19) | 0(0) | ||
| Breast cancer | No | 296(97.37) | 248(98.41) | 48(92.31) | 0.0123* |
| Yes | 8(2.63) | 4(1.59) | 4(7.69) | ||
| HT | No | 250(82.24) | 208(82.54) | 42(80.77) | 0.7610 |
| Yes | 54(17.76) | 44(17.46) | 10(19.23) | ||
| DM | No | 286(94.08) | 236(93.65) | 50(96.15) | 0.4862 |
| Yes | 18(5.92) | 16(6.35) | 2(3.85) |
aAccording to the classification system of FIGO staging (2013 version)
Abbreviation: Ca125 cancer antigen 125, EM endometriosis, LN lymph node, TH total hysterectomy, EP endometrial polyps, EIN endometrial intraepithelial neoplasm, EC endometrial cancer, HT hypertension, DM diabetic mellitus
*P < 0.05