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. 2018 May 30;18:607. doi: 10.1186/s12885-018-4528-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Effect of ERα and ERRβ on ERRβ promoter. a Schematic representation of ERRβ promoter showing two half ERE sites. b ERα regulates ERRβ classically in the presence of estrogen. c MCF7 cells were transfected with ERα, ERRβ along with ERRβ promoter and luciferase readings were obtained in the presence and absence of estrogen stimulation. Renilla readings were taken as a control and all the experiments were conducted in triplicates; statistical significance was analyzed using One-way ANOVA test and p < 0.05 considered as significant (ns- no significance, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)