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. 2018 May 29;11:30. doi: 10.1186/s13041-018-0373-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Progressive accumulation of ubiquitin/SQSTM1-positive aggregates in the anterior horn of lumbar spinal cord. a-c Representative images of double immunostaining with Ubiquitin (green) and SQSTM1 (red) in the lumbar spinal cord (L4–5) from wild-type (WT), SQSTM1 (SQSTM1), SOD1^H46R (H46R) and SQSTM1;SOD1^H46R (SQSTM1;H46R) mice at 16 weeks of age (wk) (a), 22 wk. (b), and end-stage (H46R and SQSTM1;H46R) or 28 wk. (WT and SQSTM1) (c). The nuclei were counterstained with DAPI (blue). Scale bars = 50 μm. Ubiquitin-positive aggregates and SQSTM1 aggregates were observed in the anterior horn of SOD1^H46R (H46R) and SQSTM1;SOD1^H46R (SQSTM1;H46R) mice at 22 wk. and end-stage. Arrows indicate ubiquitin-positive aggregates that are colocalized with SQSTM1