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. 2018 May 29;11:30. doi: 10.1186/s13041-018-0373-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Extensive accumulation of ubiquitin-positive aggregates in the spinal cord from SOD1^H46R-expressing mice at end-stage. a-c Representative images of double immunostaining with MAP2 (green; neuron marker) and Ubiquitin (red) (a), Ubiquitin (green) and GFAP (red; astrocyte marker) (b), Ubiquitin (green) and Iba1 (red; microglia marker) (c) in the lumbar spinal cord (L4–5) from wild-type (WT) and SQSTM1 (SQSTM1) at 28 weeks of age, SOD1^H46R (H46R) and SQSTM1;SOD1^H46R (SQSTM1;H46R) mice at end-stage. The nuclei were counterstained with DAPI (blue). Scale bars = 50 μm. b Arrows indicate colocalization of ubiquitin-positive aggregates with GFAP-positive astrocytes. c Arrows indicate colocalization of ubiquitin-positive aggregates with Iba1-positive microglia