Table 2.
Clinical and neuropathological characteristics of typical and atypical AD cases
| Case | Phenotype | Symptoms at clinical presentation | Sex | Age at death | Disease duration | NFT stage [7] | Amyloid stage [7] | Brain weight (grams) | Cause of death | PMI | ApoE |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Typical AD | Memory | F | 92 | 8 | 5 | C | 933 | Heart failure | 7:00 | 43 |
| 2 | Typical AD | Memory, disorientation | F | 84 | 4 | 4 | C | 908 | Cardiogenic shock | 4:15 | 32 |
| 3 | Typical AD | Memory, disorientation | F | 84 | 9 | 5 | C | 827 | Cachexia | 6:40 | 43 |
| 4 | Typical AD | Memory | F | 89 | 5 | 5 | C | 962 | Pneumonia | 6:28 | 43 |
| 5 | Typical AD | Memory | F | 83 | 6 | 6 | C | 1100 | Dehydration | 6:17 | 43 |
| 6 | Typical AD | Memory, behavior | F | 91 | 3 | 4 | C | 1026 | Cachexia | 6:25 | 33 |
| 7 | Typical AD | Memory, | F | 77 | 2 | 5 | C | 999 | Pneumonia | 6:05 | 33 |
| 8 | Typical AD | Memory, behavior | M | 70 | 2 | 6 | C | 1261 | Metastasized colon carcinoma | 6:20 | 43 |
| 9 | Typical AD | Memory | F | 76 | 12 | 5 | C | 1223 | Unknown | 10:45 | 44 |
| 10 | Typical AD | Memory | M | 60 | 2 | 6 | C | 1191 | Cachexia | 6:15 | 43 |
| 11 | Atypical AD | Aphasia, dyscalculia, agraphia, left-right agnosia, visuoconstruction problems | F | 65 | 6 | 6 | C | 975 | Pneumonia | 5:40 | 33 |
| 12 | Atypical AD | Aphasia, dyslexia, apraxia, visuoconstruction problems | M | 65 | 2 | 6 | C | 1057 | Cardiac insufficiency | 8:50 | 44 |
| 13 | Atypical AD | Aphasia, acalculia, fingeragnosia, apraxia | M | 64 | 7 | 5 | C | 1135 | Pneumonia | 4:45 | 42 |
| 14 | Atypical AD | Parkinsonism, falling, alien hand syndrome | F | 67 | 3 | 5 | C | 817 | Epileptic insult | 7:35 | 33 |
| 15 | Atypical AD | Aphasia, apathy, agitation | M | 59 | 6 | 6 | C | 1300 | Cachexia | 5:05 | 44 |
| 16 | Atypical AD | Aphasia, dyscalculia, dyslexia, disorientation | M | 62 | 3 | 6 | C | 1116 | Malign neuroleptic syndrome | 4:15 | 43 |
| 17 | Atypical AD | Aphasia, dyslexia, apathy, apraxia | M | 65 | 1 | 5 | C | 1150 | Euthanasia | 6:50 | 43 |
| 18 | Atypical AD | Aphasia, dyslexia, apraxia, visuospatial problems, behavior | M | 62 | 6 | 5 | B | 1153 | Cachexia | 4:40 | 33 |
| 19 | Atypical AD | Visual hallucinations, psychosis | M | 61 | 6 | 6 | C | 1355 | Pneumonia | 5:00 | 43 |
Age at death and disease duration in years; post-mortem interval in hours to minutes. Typical AD defined as more neurofibrillary tangles in the temporal compared to the parietal cortex by semi-quantitative scoring as described by Hoogendijk et al. [27] and an amnestic presentation during life. Atypical AD defined as more neurofibrillary tangles assessed by semi-quantitative scoring in the parietal compared to the temporal cortex and a non-amnestic presentation
AD Alzheimer’s disease, F female, M male, NFT neurofibrillary tangle, PMI post-mortem interval