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SU5402 exposure in developing zebrafish embryos. Embryos are exposed to SU5402 (d) at 2.5 μM (b & c) or 5 μM (e & f) in either DMSO or G4TFSA display the reported characteristics of FGF signaling inhibition compared to control (untreated (a) or DMSO exposed only (b & e)): lack of pectoral fin induction (marked by an asterisk), malformation of the otic vesicle (arrow). Lloss of MHB (open arrow head) was observed in embryos treated with 5 μM DEAB. 100× magnification
