Table 1.
Overview of studies of age-related DNA methylation changes in multiple tissues
| Species | Tissues (n) | CpGs (Platform) | Comparison of overlap at each level | Ref | ||
|---|---|---|---|---|---|---|
| CpG | Functional genomic region | Gene | ||||
| Humans | ||||||
| Human | Buccal (96), liver (147), kidney (171) Th cells (214), brain (603), SC fat (648), monocytes (1202) |
428,279 (Illumina 450 k) |
+ | + | + | Current study |
| Human | Cervix (3), bladder (5), intestine (5), kidney (6), head/neck (11), brain (12), pleura (18), placenta (19), lung (49), blood (85) | 1413 (GoldenGate) |
– | – | – | [21] |
| Human | Muscle (51), blood (71), brain (78), kidney (83) | 26,486 (27 k array) |
+ | – | – (GO terms) | [22] |
| Human | Neuron (29), glia (29), MSCs (92), whole blood (656) | 429,789 (Illumina 450 k) |
+ | – | – | [13] |
| Rodents | ||||||
| Rat | Fat (3), liver (5–6) | 40,000 (HELP assay) |
– | – | – | [45] |
| Mouse | Liver (15), heart (15), lung (16), cortex (16) | 1,230,000 (RRBS) |
+ | – | – (GO terms) | [46] |