Table 11.
FICI calculated for five different antibiotic combinations for other MDR isolates
| No. | SAM + CRO
|
SAM + AK
|
AK + LEV
|
SAM + MEM
|
CT + MEM
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| FICI | Interpretation | FICI | Interpretation | FICI | Interpretation | FICI | Interpretation | FICI | Interpretation | |
| 1* | 0.29 | Synergism | 0.04 | Synergism | 0.6 | Additive | 1 | Additive | 1.1 | Indifference |
| 2* | 0.29 | Synergism | 0.04 | Synergism | 0.6 | Additive | 1 | Additive | 1.1 | Indifference |
| 3* | 0.35 | Synergism | 1.1 | Indifference | 2 | Indifference | 1 | Additive | 2 | Indifference |
| 4* | 1 | Additive | 1.1 | Indifference | 2 | Indifference | 1 | Additive | 2 | Indifference |
| 5* | 0.5 | Synergism | 0.75 | Additive | 1.1 | Additive | 1.2 | Indifference | 2 | Indifference |
| 6* | 0.5 | Synergism | 0.75 | Additive | 1.1 | Additive | 1.2 | Indifference | 2 | Indifference |
Notes: 1*, 2*, P. aeruginosa; 3*, 4*, K. oxytoca; 5*, 6*, K. ornithinolytica. Synergism ≤0.5, additive >0.5–1, indifference >1–4.0, antagonism >4.
Abbreviations: FICI, fractional inhibitory concentration index; MDR, multidrug resistant; SAM, ampicillin/sulbactam; CRO, ceftriaxone; AK, amikacin; LEV, levofloxacin; MEM, meropenem; CT, colistin; P. aeruginosa, Pseudomonas aeruginosa; K. oxytoca, Klebsiella oxytoca; K. ornithinolytica, Klebsiella ornithinolytica.