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. 2018 May 25;13:3053–3067. doi: 10.2147/IJN.S164905

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© 2018 Li et al. This work is published and licensed by Dove Medical Press Limited

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Schematic of the structures of PFOB NPs with different shells functionalized by different ligands.

Notes: (A) Representative images of typical PFOB NPs with a lipid shell for functionalization, representing an extremely versatile platform for targeted US/pool imaging and drug delivery applications. PFOB NPs carry drugs in the lipid layer of their shell. FA and Arg–Gly–Asp are used for ligand-directed, tissue-targeted US imaging. The targeting peptides Arg–Gly–Asp, a cyclic RGD peptide, angiopep-2 and sulfatide are used for ligand-directed tissue-targeted drug delivery. (B) Representative images of other typical PFOB NPs with a polymer shell for functionalization, representing an extremely versatile platform for US pool imaging and drug delivery applications. PFOB NPs carry drugs in the polymer layer of their shell or in the center of the PFOB NPs. FA and angiopep-2 are used for ligand-directed tissue-targeted drug delivery. (C) Representative images of novel self-assembled PFOB NPs with a low PFOB content in the outer lipophilic layer, representing a platform for US pool imaging.

Abbreviations: FA, folic acid; Gd-DTPA, gadolinium diethylene triamine pentacetate acid; GO, graphene oxide; PEG-PDLLA, poly(ethylene glycol)-b-poly(d,l-lactic acid); PFOB, perfluoroo ctylbromide; PFOB NPs, perfluorooctylbromide nanoparticles; US, ultrasound.