Figure 4.
Images of the tissue distribution of PTX in EMT6 tumor-bearing mice obtained at 1 hour (A), 8 hours (B), 12 hours (C) and 24 hours (D) after intravenous administration of different PTX formulations. Values are presented as mean ± SD (n=3). *P<0.05, **P<0.01. (E) Representative images of the fluorescence of different coumarin-6 formulations in frozen slices of breast tumor tissues 1 hour after administration. (F) Representative images of the fluorescence of different coumarin-6 formulations in frozen slices of breast tumor tissue 8 hours after administration. Representative images of tumor sections were obtained at 200× magnification. PTX-NPs, PFOB NPs loaded with PTX; PTX-SNPs, sulfatide-targeted PFOB NPs loaded with PTX; coumarin-6-NPs, PFOB NPs loaded with coumarin-6; coumarin-6-SNPs, sulfatide-targeted PFOB NPs loaded with coumarin-6.
Note: Reprinted from Li X, Qin F, Yang L, Mo L, Li L, Hou L. Sulfatide-containing lipid perfluorooctylbromide nanoparticles as paclitaxel vehicles targeting breast carcinoma. Int J Nanomedicine. 2014;9:3971–3985.33
Abbreviations: PFOB NPs, perfluorooctylbromide nanoparticles; PTX, paclitaxel; SNPs, sulfatide-targeted perfluorooctylbromide nanoparticles.