. 2018 May 25;13:3053–3067. doi: 10.2147/IJN.S164905

Table 1.

Broad applications of PFOB NPs

No.	Main component of the shell	Application	Target epitope	References
1	Polymer (PLGA, PCL, PLA, PEG-PDLLA or PLGA-PEG and ingredients)	US pool imaging		9, 28, 39, 44, 52, 58
2	Lipids (lecithin, cholesterol and ingredients)	US pool imaging	–	30
2	Lipids (lecithin, cholesterol and ingredients)	Tumor-targeted US imaging	FR or α_vβ₃ integrin	63, 71, 72
3	Lipids (lecithin, cholesterol and ingredients)	Loading different drugs for several therapies	VCAM-1, α_vβ₃ integrin, α₅β₁ integrin, TN-C or LRP-1	33, 96, 99, 104, 105, 119–122, 127–129
4	Polymer (PLGA-PEG, Bi₂Se₃ or PLGA and ingredients)	Cancer therapy	LRP-1 or none	17, 106, 107, 112

Abbreviations: FR, folate receptor; LRP-1, low-density lipoprotein receptor-related protein-1; PCL, polycaprolactone; PEG-PDLLA, poly(ethylene glycol)-b-poly(d,l-lactic acid); PFOB NPs, perfluorooctylbromide nanoparticles; PLA, poly(lactic acid); PLGA, poly(lactide-co-glycolide) acid; PLGA-PEG, poly(lactide-co-glycolide) acid-polyethylene glycol; TN-C, tenascin-C; US, ultrasound; VCAM-1, vascular cell adhesion molecule 1.