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. 2018 May 25;11:3141–3147. doi: 10.2147/OTT.S143465

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© 2018 Chen et al. This work is published and licensed by Dove Medical Press Limited

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miR-134 inhibits phosphorylation of eIF4E and downregulates Mcl-1 and bcl2.

Notes: (A) Quantification of Mnk1/2 mRNA expression in K562/A02 cells. (B) Quantification of Mnk1/2 mRNA expression in HL-60/ADM cells. (C) Effect of miR-134 on the expression of the phosphorylation of Erk1/2, p38, eIF4E, Mcl-1, and bcl2 in K562/A02 cells. (D) Effect of miR-134 on the expression of the phosphorylation of Erk1/2, p38, eIF4E, Mcl-1, and bcl2 in HL-60/ADM cells. **p<0.01.

Abbreviations: eIF4E, eukaryotic initiation factor 4E; NC, normal control; p-eIF4E, phosphorylation-eIF4E; p-Erk1/2, phosphorylation-Erk1/2; p-p38, phosphorylation-p38.