Figure 2.

LUAD specific lncRNA-miRNA-mRNA ceRNA network. LUAD specific lncRNA-miRNA regulatory network (A), miRNA-mRNA regulatory network (B) and ceRNA network (C). The ceRNA network is acquired by integrating lncRNA-miRNA and miRNA-mRNA regulatory network. Squares, triangles and circles indicate lncRNAs, miRNAs and mRNAs, respectively. Upregulated lncRNAs, miRNAs and mRNAs in LUAD are shown as red and downregulated ones shown as green. Red lines and blue lines indicate lncRNA-miRNA and miRNA-mRNA regulatory relationships, whereas gray lines indicate protein–protein interactions of corresponding mRNAs.

Abbreviation: LUAD, lung adenocarcinoma.