Table 4.

Adverse events in all trials combined

Adverse event	No. of participants (%)				P *
	Placebo (n = 1289)	Aspirin in any dose (n = 1678)	Aspirin, 81 or 160 mg/d (n = 450)	Aspirin, 300 or 325 mg/d (n = 1228)
Death	11 (0.85)	16 (0.95)	3 (0.67)	13 (1.06)	.85
Myocardial infarction	4 (0.31)	8 (0.48)	2 (0.44)	6 (0.49)	.57
Stroke	0 (0.00)	12 (0.66)	3 (0.67)	9 (0.65)	.002
Major bleeding	36 (2.79)	42 (2.50)	11 (2.44)	31 (2.52)	.64
Invasive cancer	24 (1.86)	44 (2.62)	18 (4.00)	26 (2.12)	.18
Colorectal cancer	8 (0.62)	9 (0.54)	2 (0.44)	7 (0.57)	.81
Any event above	71 (5.51)	104 (6.20)	29 (6.44)	75 (6.12)	.48

^* P values (two-sided) are from Fisher's exact test comparing placebo vs aspirin in any dose.