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Persons born in regions of high or intermediate HBV endemicity (HBsAg prevalence of ≥2%) |
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Africa |
All countries |
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North, Southeast, East Asia |
All countries |
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Australia and South Pacific |
All countries except Australia and New Zealand |
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Middle East |
All countries except Cyprus and Israel |
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Eastern Europe |
All countries except Hungary |
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Western Europe |
Malta, Spain, and indigenous populations of Greenland |
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North America |
Alaskan natives and indigenous populations of Northern Canada |
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Mexico and Central America |
Guatemala and Honduras |
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South America |
Ecuador, Guyana, Suriname, Venezuela, and Amazonian areas |
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Caribbean |
Antigua-Barbuda, Dominica, Grenada, Haiti, Jamaica, Saint Kitts and Nevis, Saint Lucia, and Turks and Caicos Islands |
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US-born persons not vaccinated as an infant whose parents were born in regions with high HBV endemicity (≥8%)*
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Persons who have ever injected drugs*
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Men who have sex with men*
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Persons needing immunosuppressive therapy, including chemotherapy, immunosuppression related to organ transplantation, and immunosuppression for rheumatologic or gastroenterologic disorders |
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Individuals with elevated ALT or AST of unknown etiology*
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Donors of blood, plasma, organs, tissues, or semen |
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Persons with end-stage renal disease, including predialysis, hemodialysis, peritoneal dialysis, and home dialysis patients*
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All pregnant women |
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Infants born to HBsAg-positive mothers*
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Persons with chronic liver disease, eg, HCV*
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Persons with HIV*
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Household, needle-sharing and sexual contacts of HBsAg-positive persons*
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Persons who are not in a long-term, mutually monogamous relationship (eg >1 sex partner during the previous 6 months)*
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Persons seeking evaluation or treatment for a sexually transmitted disease*
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Health care and public safety workers at risk for occupational exposure to blood or blood-contaminated body fluids*
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Residents and staff of facilities for developmentally disabled persons*
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Travelers to countries with intermediate or high prevalence of HBV infection*
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Persons who are the source of blood or body fluid exposures that might require post-exposure prophylaxis |
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Inmates of correctional facilities*
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Unvaccinated persons with diabetes who are aged 19 through 59 years (discretion of clinician for unvaccinated adults with diabetes who are aged ≥60 years)*
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