Table 4.
Interpretation of Screening Tests for HBV Infection
| Screening Test Results | Interpretation | Management | Vaccinate? | ||
|---|---|---|---|---|---|
| HBsAg | Anti-HBc | Anti-HBs | |||
| + | + | − | Chronic hepatitis B | Additional testing and management needed | No |
| − | + | + | Prior HBV infection, resolved | No further management unless immunocompromised or undergoing chemotherapy or immunosuppressive therapy | No |
| − | + | − | Prior HBV infection, resolved or false-positive | HBV DNA testing if immunocompromised patient | Yes, if not from area of intermediate or high endemicity |
| − | − | + | Immune | No further testing | No |
| − | − | − | Uninfected and not immune | No further testing | Yes |