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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Hepatology. 2018 Apr;67(4):1560–1599. doi: 10.1002/hep.29800

Table 9.

Factors Influencing the Choice of Prophylaxis of HBsAg-Positive Liver Transplant Recipients

Long-term HBIG Plus Indefinite NAs Perioperative Only or No HBIG Plus Indefinite NAs
Patient Factors Questionable adherence Adherent
High share of cost for medications
Virologic Factors Presence of drug resistance or HBV DNA detectable at time of LT
HIV coinfection
HDV coinfection
No drug-resistant variants
Undetectable to low (<100 IU/mL) HBV DNA at time of LT
Absence of HIV and HDV coinfection
Other Access to HBIG
Lack access to entecavir or tenofovir (TDF or TAF)
Access to entecavir or tenofovir (TDF or TAF)

NA: nucleos(t)ide analogues; HBIG: hepatitis B immune globulin; TDF: Tenofovir dipovoxil fumarate; TAF: tenofovir alafenamide; LT: liver transplant; HIV: human immunodeficiency virus; HDV: hepatitis D virus