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. Author manuscript; available in PMC: 2018 Oct 5.
Published in final edited form as: Nature. 2018 Mar 28;556(7699):64–69. doi: 10.1038/nature26158

Figure 4. An intact GATOR1 is necessary for mTORC1 inhibition upon amino acid starvation.

Figure 4

a. Three loops in the SABA domain of Depdc5 mediate the Depdc5-Nprl2 interaction. Loops A, B, and C are colored in red, orange, and blue, respectively. b. Compound mutant of loop A and loop B in Depdc5 disrupts GATOR1 assembly. c. Expression of Dedpc5 mutant that prevents GATOR1 assembly does not restore normal mTORC1 signaling in cells lacking Depdc5. Data (b & c) are the representatives of two independent experiments.