Table 1.

Selection criteria

MAKE BETTER study	Cortisol study
Inclusion criteria	Same as the MAKE BETTER study but Aged older than 20 years
Aged older than 7 years	Free of psychotropic medications for at least 1 month
DSM IV diagnoses of major depressive disorder, dysthymic disorder, and depressive disorder not otherwise specified (NOS) as ascertained by the MINI
Score ≥14 on the Hamilton Depression Rating Scale
Female patients with child-bearing potential who did not plan to become pregnant during the study period and agreed to use an appropriate contraceptive method
Able to complete the questionnaires
Able to understand the objective of the study and sign informed consent form
Exclusion criteria
Unstable or uncontrolled medical condition	Same as the MAKE BETTER study
Unable to complete the psychiatric assessment or comply with the medication regimen due to a severe physical illness
Current or lifetime DSM-IV diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, schizophreniform disorder, psychotic disorder NOS, or other psychotic disorders
History of organic psychosis, epilepsy, or seizure disorder
History of anticonvulsant treatment
Hospitalization for any psychiatric diagnosis except depressive disorder (e.g., alcohol/drug dependence)
Electroconvulsive therapy for the current depressive episode
Pregnant or breastfeeding

MAKE BETTER: MAKE Biomarker discovery for Enhancing anTidepressants Treatment Effect and Response, DSM-IV: Diagnostic and Statistical Manual 4th edition, MINI: Mini-International Neuropsychiatric Interview