Table 2.

Schedule of assessment for MAKE BETTER study

Assessments	Base-line	1 weeks	2 weeks	3 weeks	6 weeks	3 Month	6 Month	12 Month	15 Month	18 Month	21 Month	24 Month
Clinical assessment
Socio-demographic characteristics	√
Psychological characteristics
Personality	√					√		√
Social support	√					√		√				√
Stress-related status	√					√		√				√
Outcomes of depression
Depressive symptom	√	√	√	√	√	√	√	√	√	√	√	√
Functional disability	√	√	√	√	√	√	√	√	√	√	√	√
Suicidality	√	√	√	√	√	√	√	√	√	√	√	√
Quality of life	√	√	√	√	√	√	√	√	√	√	√	√
Biological assessment
Blood biomarker	√							√
Salivary cortisol (cortisol study only)	√		√		√	√	√
Electrocardiography	√							√
Resting BP, body mass index	√		√		√	√	√	√	√	√	√	√
Treatment related assessment
Antidepressants, dosage, duration	√	√	√	√	√	√	√	√	√	√	√	√
Adverse events	√	√	√	√	√	√	√	√	√	√	√	√
Withdrawal	√	√	√	√	√	√	√	√	√	√	√	√

MAKE BETTER: MAKE Biomarker discovery for Enhancing anTidepressants Treatment Effect and Response, BP: blood pressure