Table 4.
Changes from baseline in SGRQ total score at week 52 by categories of change in FVC % predicted, change in UCSD-SOBQ score and PGI-C at week 52
| Anchor | n | Change from baseline in SGRQ total score at week 52 | Comparison versus stable | |
| Mean (SD) | Adjusted mean (SE) | P values | ||
| Change in FVC % predicted | ||||
| Deterioration >10% | 152 | 13.1 (15.6) | 12.7 (1.6) | <0.001 |
| Deterioration >5–≤10% | 194 | 4.8 (15.4) | 4.1 (1.5) | 0.005 |
| Deterioration >2–≤5% | 141 | 0.7 (14.4) | 0.0 (1.6) | 0.998 |
| Stable (≤2% change) | 181 | 1.4 (13.7) | – | |
| Improvement >2–≤5% | 78 | −0.6 (13.9) | −1.1 (1.9) | 0.566 |
| Improvement >5–≤10% | 56 | −4.4 (14.1) | −5.0 (2.2) | 0.022 |
| Improvement >10% | 21 | −6.8 (15.2) | −6.1 (3.3) | 0.065 |
| Change in UCSD-SOBQ | ||||
| Deterioration ≥5 | 360 | 11.1 (15.0) | 13.5 (1.2) | <0.001 |
| Stable (change <5) | 191 | 0.0 (9.8) | – | – |
| Improvement ≥5 | 192 | −8.1 (14.1) | −4.9 (1.4) | <0.001 |
| PGI-C | ||||
| Much worse/very much worse (6–7) | 73 | 20.4 (16.6) | 20.1 (1.7) | <0.001 |
| A little worse (5) | 156 | 10.1 (12.4) | 8.2 (1.3) | <0.001 |
| No change (4) | 303 | 3.3 (12.9) | – | |
| A little better (3) | 182 | 0.5 (13.9) | −2.0 (1.2) | 0.098 |
| Much better/very much better (1–2) | 116 | −9.7 (14.9) | 12.1 (1.4) | <0.001 |
FVC, forced vital capacity; PGI-C, Patient ’s Global Impression of Change; SGRQ, St George’s Respiratory Questionnaire; UCSD-SOBQ, University of California San Diego Shortness of Breath Questionnaire.