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. 2018 May 14;12(5):e0006450. doi: 10.1371/journal.pntd.0006450

Fig 6. Comparing metabolic profiles of DTT and AN5568 treated cells.

Fig 6

A heatmap was generated to highlight similarities and differences in metabolism after treatment with the ER stress inducer dithiothreitol (DTT) and AN5568. A) AdoMet metabolism was unaffected by DTT-treatment. B) Components of the oxidative stress response pathway were altered after both treatments. In particular, DTT treatment led to a significant decrease in trypanothione disulphide. C) Both DTT and AN5568 treatment result in increased levels of modified lysines and arginines, suggesting these are part of a conserved trypanosomatid stress response. WT; wild-type untreated, AN5568; wild-type cells treated with AN5568 for 6 hours at 10× EC50, DTT; wild-type cells treated with DTT for 6 hours at 10× EC50.