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. 2018 May 24;122(11):1608–1624. doi: 10.1161/CIRCRESAHA.118.313058

Figure 4.

Figure 4.

Proposed roles for vascular wall resident progenitor cells (PCs) in lesion formation. The adventitia is a dynamic layer in active communication with the other vessel wall layers, and it contains various cell types, including PCs (red), mesenchymal stem cells (MSCs in green), macrophages (blue), fibroblasts (yellow), and pericytes (orange) surrounding the adventitial vasa vasorum, among others. Adventitial PCs, expressing the stem cell marker Sca-1 (red), have the ability to migrate to the lesions and to differentiate into smooth muscle cells (SMCs), thus contributing to the intimal SMCs pool. EC indicates endothelial cell.