Figure 2.

Chromatin conformation capture data reveal similarities in chromatin organization between cell types. A, Representative contact matrices from 14 human tissues (A), and their A/B compartmentalization profiles (B), demonstrate similarities at the scale of topologically associated domains (TADs) and compartmentalization. AD indicates adrenal gland; AO, aorta; BL, bladder; CO, prefrontal cortex; HC, hippocampus; LG, lung; LI, liver; LV, left ventricle; OV, ovary; PA, pancreas; PO, psoas muscle; RV, right ventricle; SB, small bowel; and SX, spleen. Black track represents mm10 gene density on chromosome 19. Data are from the ENCODE (Encyclopedia of DNA Elements) database. Adapted from Schmitt et al²¹ with permission. Copyright ©2016, the Authors.