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. 2018 May 24;122(11):1586–1607. doi: 10.1161/CIRCRESAHA.118.311597

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© 2018 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 6. — Model for epigenomic changes in development and disease. Development is accompanied by changes in chromatin structure and regulation to endow terminally differentiated cells with stable transcriptomes. Disease upsets this balance, transitioning select regions of the genome into more dynamic conformations through effects on chromatin structure, enhancer-gene looping and alterations in histone modification, DNA methylation, and other factors. This model is based on findings reviewed in the current paper and adapted from Rosa-Garrido et al¹⁹¹ with permission. Copyright ©2017, the American Heart Association.