Skip to main content
. Author manuscript; available in PMC: 2018 May 30.
Published in final edited form as: J Med Chem. 2018 Apr 3;61(7):3209–3217. doi: 10.1021/acs.jmedchem.8b00343

Table 3.

UT-A1 Inhibition by 1,2,4-Triazoloquinoxalines with Different R3

graphic file with name nihms964715u4.jpg
compound R1 R2 R3 isolated yield
(%)		 UT-A1 IC50
(µM)
8be A H CH3 65 2.7
8bf A CH2CH3 CH3 73 1.4
8bg A CH(CH3)2 CH3 99 1.2
8bh A CH2CH2CH3 CH3 80 0.4
8bi A H Cl 70 >20
8bj A H F 67 1.2
8bk B H F 40 1.5
8bl A CH2CH2CH3 F 48 0.3