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. 2001 Oct 2;98(21):12044–12049. doi: 10.1073/pnas.221430898

Figure 1.

Figure 1

Sustained chromatid catenation induces mitotic delay in normal and A-T cells. (A) Normal and A-T lymphoblasts were sham-treated, irradiated with 1 Gy of γ-rays (IR), incubated in 2 μM ICRF-193, or incubated with DMSO solvent. Two hours after treatment or addition of drug, mitotic index was quantified as described in Materials and Methods. The results for IR and ICRF-193 are expressed as a percentage of the untreated control (mean + SD; n = 3–4 for all but GM03332C, where n = 2). (B) The mean values obtained in A were expressed as the average percentage of the untreated control for normal and A-T cells (mean + SD, n = 3). *, The mean inhibition of mitosis in A-T cells after IR was significantly less than in normal cells (Student's t test, P < 0.05).