Skip to main content
. 2018 Apr 27;9(32):22509–22522. doi: 10.18632/oncotarget.25147

Figure 2. ERβ alters p53-dependent transcription in response to chemotherapy.

Figure 2

(A) mRNA levels of p53 target genes in MCF-7 cells following transfection with control (Control) or siRNA#1 against ERβ and treatment with vehicle or 20 μM cisplatin for 24 hours. Values were normalized to the untreated control cells. (B) mRNA expression of p53 target genes in control and ERβ-expressing MCF-7 cells following treatment with vehicle or 20 μM cisplatin. Values were normalized to the untreated control cells. (C) Left: mRNA levels of p53 target genes in control and ERβ-expressing ZR-75-1 cells after treatment with vehicle or 20 μM cisplatin. Right: mRNA and protein levels of ERβ in control and ERβ-expressing ZR-75-1 cells. (D) Left: Expression of p53 target genes in control and ERβ-expressing MCF-10A cells. Right: mRNA and protein levels of ERβ in control and ERβ-expressing MCF-10A cells. In all graphs, values represent the mean ± S.D. of three experiments; *P ≤ 0.05.