Fig. 1.

Diclofenac increases gastric hemorrhages and MPO levels. Mice were fasted for 24 h, administered diclofenac (100 mg/kg, p.o.) or vehicle, and stomachs were harvested and mucus collected 6 h later. In mucus samples, diclofenac dose-dependently increases gastric hemorrhage length and gastric mucus myeloperoxidase (MPO) levels in male (n = 8) (A, B) and female (n = 8 or 9) (C, D) mice. Data presented as mean ± S.E.M.; *P < 0.05 vs. vehicle; ** P < 0.01 vs. vehicle