Fig. 2.

MAGL inhibition prevents the development of gastric hemorrhages induced by diclofenac in male (A) and female (C) mice. Mice were fasted for 22 h, administered JZL184 (40 mg/kg, i.p.) or vehicle, then diclofenac (100 mg/kg, p.o., black bars) or vehicle (white bars) 2 h later, and stomachs and gastric contents were harvested 6 h later. Diclofenac and JZL184 do not alter gastric acid secretions in either male (B) or female (D) mice 6 h or 8 h after administration, respectively. Data presented as mean ± S.E.M. (n = 7-10); **P < 0.01 vs. vehicle/vehicle; ## P < 0.01 vs. vehicle/diclofenac