Fig. 4.

MAGL inhibition decreases gastric emptying. Mice were fasted for 24 h. The mice were administered JZL184 (40 mg/kg) or vehicle, then 2 h later, diclofenac sodium (100 mg/kg, p.o., black bars) or vehicle (p.o., white bars) was administered 1 h before oral administration of phenol red (0.5 mg/ml). JZL184 and diclofenac significantly reduce gastric emptying of phenol red as compared to control mice. Data presented as mean ± S.E.M. (n = 8); * P < .05 vs vehicle treatment.