. Author manuscript; available in PMC: 2019 Jul 1.

Published in final edited form as: Cell Mol Neurobiol. 2018 Apr 5;38(5):1099–1106. doi: 10.1007/s10571-018-0579-4

Table 1.

Patient and Tumor Characteristics

	Sex	Age at diagnosis	Age CVD Started	Initial Site of Disease	Sites of Metastasis	Family History	Biochemical Phenotype	BP treatment	Mutation Status
	Sex	Age at diagnosis	Age CVD Started	Initial Site of Disease	Sites of Metastasis	Family History	Biochemical Phenotype	BP treatment	Gene	Nucleotide	Amino Acid	Exon
1	F	18	35	Adrenal	Liver, bones	Pancreatic cancer	N	No	SDHB	136 C→T	Arg⁴⁶→Stop	2
2	M	24	31	Paraspinal (T3-4)	Lung, nodes, spine, bones	Cervical cancer	NEG	No	SDHB	136 C→T	Arg⁴⁶→Stop	2
3	M	40	42	Renal, paraspinal	Renal, bones, paraspinal, liver	Hodgkin’s lymphoma	N	Yes	SDHB	136 C→T	Arg⁴⁶→Stop	2
4	F	51	52	Retroperitoneum	Lung, spine, bones	No Cancer	N	Yes	SDHB	IVS3+1 G→A	Splice	3
5	M	32	38	Extra-adrenal	Liver, nodes	PHEO	N, D	Yes	SDHB	72+1 G→T	(−)	Intron 1
6	M	27	29	Pelvic	Lung	PHEO	A, N, D	Yes	SDHB	196 C→T	Cys⁶⁶→Tyr⁶⁶	(−)
7	F	38	41	Adrenal, tail pancreas	Pelvic bones, spine, liver	No Cancer	NEG	Yes	SDHB	136 C→T	Arg⁴⁶→Stop	2
8	F	21	25	Adrenal	Liver	No Cancer	N, D	Yes	SDHB polymorphism	487 T→C	Ser¹⁶³→Pro¹⁶³	5
9	M	34	35	Retroperitoneum	Nodes	Glomus tumor	N, D	Yes	SDHB	IVS3-1 G→C	Splice	3
10	M	50	50	Adrenal	Peri-aortic nodes, liver	PHEO/PGL	N, D	Yes	SDHB	Deletion	Deletion	1
11	M	37	40	Peri-aortic nodes	Liver	PGL	N, D	Yes	SDHB	590 C→G	Pro¹⁹⁷→Arg¹⁹⁷	6
12	F	32	41	Adrenal	Chest wall, liver	PGL	N	No	SDHB	Deletion	Deletion	1

Abbreviations: PHEO: Pheochromocytoma; PGL: Paraganglioma; SDHB: Succinate Dehydrogenase Complex Subunit B; IVS: Intervening sequence; A: Adrenergic; D: Dopaminergic; N: Noradrenergic; NEG: Biochemically negative;