Skip to main content
. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Neuroimage. 2018 May 5;176:313–320. doi: 10.1016/j.neuroimage.2018.05.015

Table 1.

Full kinetic parameters of PET with [11C]SAR127303.

Region 2-TCMi Patlak plot
K1
(mL/cm3/min)		 k2 (/min) k3(/min) K1/k2(mL/cm3) Ki
(mL/cm3/min)		 λk3
(mL/cm3/min)		 Slope (Ki)
(mL/cm3/min)		 Intercept
(mL/cm3)
Cingulate cortex 0.68 ± 0.15 0.12 ± 0.04 0.08 ± 0.04 5.88 ± 2.02 0.26 ± 0.09 0.43 ± 0.19 0.24 ± 0.07 6.27 ± 3.39
(1.8 ± 0.4) (7.4 ± 2.3) (6.7 ± 1.7) (5.9 ± 2.0) (8.7 ± 2.1) (9.0 ± 2.5) (1.1 ± 0.6) (17.8 ± 18.4)
Striatum 0.67 ± 0.15 0.13 ± 0.04 0.08 ± 0.03 4.62 ± 1.38 0.24 ± 0.08 0.40 ± 0.16 0.23 ± 0.06 6.53 ± 3.94
(1.4 ± 0.3) (5.4 ± 1.7) (4.9 ± 1.3) (4.3 ± 1.4) (6.4 ± 1.7) (6.5 ± 1.9) (0.8 ± 0.7) (9.7 ± 7.5)
Hippocampus 0.62 ± 0.14 0.14 ± 0.04 0.08 ± 0.03 4.40 ± 1.21 0.22 ± 0.07 0.35 ± 0.14 0.20 ± 0.06 5.68 ± 3.86
(1.5 ± 0.3) (5.6 ± 1.7) (5.0 ± 1.3) (4.4 ± 1.4) (6.6 ± 1.7) (6.7 ± 1.9) (0.8 ± 0.8) (8.2 ± 6.0)
Thalamus 0.68 ± 0.15 0.16 ± 0.04 0.07 ± 0.03 3.19 ± 0.77 0.21 ± 0.07 0.31 ± 0.12 0.19 ± 0.05 5.92 ± 3.82
(1.4 ± 0.3) (4.6 ± 1.3) (4.2 ± 1.1) (3.5 ± 1.1) (5.6 ± 1.4) (5.5 ± 1.5) (1.1 ± 1.3) (8.8 ± 6.9)
Hypothalamus 0.61 ± 0.15 0.20 ± 0.05 0.07 ± 0.02 3.28 ± 0.76 0.15 ± 0.05 0.21 ± 0.07 0.14 ± 0.04 4.28 ± 2.19
(1.7 ± 0.4) (5.0 ± 1.4) (4.7 ± 1.1) (3.7 ± 1.0) (6.4 ± 1.4) (6.0 ± 1.4) (1.3 ± 1.0) (14.5 ± 12.3)
Pons 0.66 ± 0.17 0.20 ± 0.05 0.06 ± 0.02 4.43 ± 1.16 0.15 ± 0.05 0.20 ± 0.07 0.14 ± 0.04 4.35 ± 2.33
(1.2 ± 0.2) (3.5 ± 0.9) (3.4 ± 0.8) (2.5 ± 0.7) (4.5 ± 1.1) (4.2 ± 1.1) (0.8 ± 0.5) (7.9 ± 4.8)
Cerebellum 0.71 ± 0.18 0.18 ± 0.04 0.07 ± 0.03 4.10 ± 1.11 0.20 ± 0.07 0.29 ± 0.11 0.19 ± 0.06 5.39 ± 2.80
(1.4 ± 0.3) (4.5 ± 1.2) (4.1 ± 1.0) (3.4 ± 1.0) (5.6 ± 1.3) (5.3 ± 1.4) (0.6 ± 0.6) (7.3 ± 5.7)

Values in parentheses are percentages of coefficient of variation (%COV). Data are represented as mean ± s.d. (n = 7).