Figure 7.

RNA/DNA Hybrid Interactome Helicases Are Amplified in Human Cancers

(A) Enrichment of DEAD and DEAH/RHA helicases in the RNA/DNA hybrid interactome.

(B) Gain (red) and loss (blue) of RNA/DNA hybrid-interacting DEAD/H helicases in cancer. The y axis shows the percentage of the total tested cancer samples based on copy number variations (COSMIC database).

(C) Transcriptional expression changes of RNA/DNA hybrid-interacting DEAD/H helicases in cancer. The y axis shows the number of cancer studies (ONCOMINE database).

(D) Model showing the role of the RNA/DNA hybrid interactome and the top candidate DHX9 in regulating R-loop balance in health and disease.