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. 2018 May 30;50(5):68. doi: 10.1038/s12276-018-0095-0

Fig. 1. Topical application of VTI-1002 gel accelerates diabetic burn wound closure.

Fig. 1

a VTI-1002 is retained in diabetic skin after single topical application. b Representative digital images of diabetic wounds treated with vehicle or VTI-1002 gel captured over first 18 days wound healing period. c Comparison of scab falling-off days between vehicle control group and VTI-1002 treatment group (n = 10 per group). Results presented in bar graph are expressed as mean ± SEM. Results presented in box-and-whiskers plot are expressed as median and min/max value, **P < 0.01 by Student's t test. d Percentage of mice achieving over 50% wound closure in vehicle control and VTI-1002 treatment group. e Comparison of wound size over the 30-day healing period between vehicle control group and VTI-1002 treatment group (n = 10 per group). Results are expressed as mean ± SEM, P < 0.0001 by two-way ANOVA. Red rectangle indicates the window when significant differences at each day are observed between vehicle control group and VTI-1002 treatment group. f Comparison of wound size at day 3, day 6, day 9, day 12, day 15, and day 18 between vehicle control group and VTI-1002 treatment group (n = 10 per group). Results are expressed as median and min/max value, *P < 0.05, **P < 0.01, ***P < 0.001 by Student's t test