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Biofunctional characteristics of VTI-1002
| GzmB inhibition potency | |||
|---|---|---|---|
| Human GzmB (Ki): | 4.4 ± 2.0 nM | Mouse GzmB (IC50): | 179 ± 18 nM |
| Target selectivity | |||
|---|---|---|---|
| Protease | IC 50 | Protease | IC 50 |
| Caspase-3: | No inhibition | Caspase-9: | »300 μM |
| Caspase-4: | No inhibition | Caspase-10: | No inhibition |
| Caspase-5: | No inhibition | Cathepsin G: | No inhibition |
| Caspase-7: | No inhibition | Neutrophil elastase: | No inhibition |
| Caspase-8: | »300 μM | ||
