Table 1.
Predicted number of UPP components in 8 analyzed genomes.
| HMM | Tc | Tbg | Tbb | Tcm | Tcg | Tr | Tv | Hs |
|---|---|---|---|---|---|---|---|---|
| Ubiquitin and ubiquitin like proteins | ||||||||
| Ubiquitin* | 31 | 16 | 18 | 1 | 4 | 20 | 2 | 45 |
| UFM1 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 1 |
| URM1 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 3 |
| ATG8 | 3 | 3 | 3 | 0 | 0 | 0 | 0 | 15 |
| APG12 | 1 | 3 | 3 | 0 | 0 | 0 | 0 | 1 |
| Ubiquitin-activating enzymes (E1) | ||||||||
| THIF | 23 | 12 | 12 | 12 | 5 | 13 | 1 | 42 |
| Ubiquitin-conjugating enzymes (E2) | ||||||||
| UQ_con | 29 | 17 | 17 | 9 | 4 | 14 | 1 | 87 |
| Ubiquitin ligases (E3) | ||||||||
| CULLIN | 13 | 8 | 7 | 8 | 5 | 7 | 1 | 16 |
| UBOX | 5 | 4 | 4 | 4 | 0 | 2 | 0 | 20 |
| FBOX | 8 | 11 | 9 | 9 | 2 | 6 | 0 | 111 |
| HECT | 16 | 11 | 11 | 12 | 7 | 13 | 0 | 45 |
| RING | 67 | 44 | 44 | 30 | 13 | 33 | 5 | 631 |
| Deubiquitinases (DUBs) | ||||||||
| WLM | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| OTU | 8 | 4 | 4 | 4 | 0 | 4 | 0 | 21 |
| JOSEPHIN | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 13 |
| Peptidase_C48 | 3 | 1 | 1 | 2 | 2 | 1 | 0 | 16 |
| Peptidase_C54 | 2 | 2 | 2 | 2 | 1 | 2 | 0 | 7 |
| Peptidase_C97 | 10 | 6 | 6 | 5 | 3 | 3 | 0 | 8 |
| UCH* | 31 | 16 | 15 | 16 | 8 | 15 | 1 | 123 |
| JAB | 14 | 5 | 6 | 4 | 3 | 6 | 1 | 17 |
| Ribosomal_S19e | 2 | 2 | 2 | 0 | 0 | 1 | 0 | 5 |
| Total | 269 | 168 | 167 | 119 | 58 | 141 | 12 | 1227 |
The number of UPP components identified in Trypansoma cruzi is highest among all species of parasite. Symbol - * indicates that three of the Uniprot Ids are in both Ubiquitin category of Ubiquitin and ubiquitin-like proteins and UCH category of Deubiquitinases (Q4CYB0, Q4CL15, Q4D313). Abbreviations used: Trypanosoma cruzi (Tc), Trypanosoma brucei gambiense (Tbg), Trypanosoma brucei brucei (Tbb), Trypanosoma cruzi marinkellei (Tcm), Trypanosoma congolense (Tcg), Trypanosoma rangeli (Tr), Trypanosoma vivax (Tv), Homo sapiens (Hs).