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. 2018 May 30;8:8421. doi: 10.1038/s41598-018-26525-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of microRNAs associated with osteoporosis. Box plots show the levels of microRNAs determined by RT-qPCR in clinical samples associated with the development of osteoporosis. The data includes 20 male participants, comprising one male control, 11 with osteopaenia and 8 with osteoporosis. These numbers were too small to warrant separate analysis. Panel (a), box plots show the levels of hsa-miR-122-5p among non-osteoporotic controls, osteopaenia and osteoporosis patients (P = 0.00235); Panel (b), box plots show a statistically significant correlation of hsa-miR-122-5p within the osteoporosis patients who had fracture (P = 0.03); Panel (c), box plots show the levels of hsa-miR-4516 among non-osteoporotic controls, osteopaenia and osteoporosis patients (P = 0.0089); Panel (d), box plots show that hsa-miR-4516 is associated with osteoporosis patient with fracture (P < 0.0002); Panel (e), the levels of hsa-miR-122-5p in clinical samples significantly increased with increasing lumbar spine (L2-L4) of the subject (P = 0.0083); Panel (f), the levels of hsa-miR-4516 in clinical samples significantly increased with increasing lumbar spine (L2-L4) of the subject (P = 0.00022); Panel (g), box plots show the levels of hsa-miR-122-5p among non-osteoporotic controls, low BMD patients without fracture and low BMD patients with fracture (P = 0.097); Panel (h), box plots show the levels of hsa-miR-4516 among non-osteoporotic controls, low BMD patients without fracture and low BMD patients with fracture (P = 0.00014).