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. 2018 May 30;8:8412. doi: 10.1038/s41598-018-26840-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kinomic profiling of GBM xenolines identify actionable kinase targets for testing. (A) Kinomic probes for showing inverse correlation between phospho-peptide intensity and intracranial survival in days for 19 GBM PDX. Correlation (R²) is indicated for each peptide probe. (B) Probe Number (UniProt ID) and corresponding phosphorylatable peptide sequence with tyrosine residue indicated with bold large font are shown. Predicted upstream kinases for phosphopeptide sequences are indicated (See Materials and Methods for upstream kinase identification strategy). Selected drugs for subsequent characterization are shown with predominant kinase targets.