. 2018 May 30;8:8412. doi: 10.1038/s41598-018-26840-4

Table 1.

Synergistic combination index (CI) values of WP1066, Selumetinib, Crizotinib, and Cediranib SMIs in combination for all xenolines at Day 7.

Xenoline	Combination Dosing	CI	Description
XD456
	Cediranib IC_37.5 + Crizotinib IC_12.5	0.76	Synergism
	Crizotinib IC_37.5 + WP1066 IC_12.5	0.80	Synergism
	Crizotinib IC_25 +Cediranib IC₂₅	0.85	Synergism
X1066
	Cediranib IC_37.5 + Selumetinib IC_12.5	0.71	Synergism
	Selumetinib IC_25 +Cediranib IC₂₅	0.72	Synergism
	Cediranib IC_37.5 + Crizotinib IC_12.5	0.96	Synergism
	Crizotinib IC_37.5 + Selumetinib IC_12.5	0.97	Synergism
JX10UAB
	Crizotinib IC_37.5 + Selumetinib IC_12.5	0.57	Synergism
	Cediranib IC_37.5 + Selumetinib IC_12.5	0.75	Synergism
	Selumetinib IC_25 +Crizotinib IC₂₅	0.81	Synergism
	WP1066 IC_37.5 + Selumetinib IC_12.5	0.91	Synergism
	Cediranib IC_37.5 + Crizotinib IC_12.5	0.93	Synergism
	Crizotinib IC_37.5 + Cediranib IC_12.5	0.95	Synergism
JX22P
	Crizotinib IC_37.5 + Selumetinib IC_12.5	0.08	Synergism
	Crizotinib IC_37.5 + WP1066 IC_12.5	0.15	Synergism
	Selumetinib IC_25 +Crizotinib IC₂₅	0.22	Synergism
	Crizotinib IC_37.5 + Cediranib IC_12.5	0.28	Synergism
	WP1066 IC_37.5 + Selumetinib IC_12.5	0.31	Synergism
	WP1066 IC_37.5 + Crizotinib IC_12.5	0.47	Synergism
	Selumetinib IC_25 +Cediranib IC₂₅	0.60	Synergism
	Crizotinib IC_25 +Cediranib IC₂₅	0.61	Synergism
	WP1066 IC_37.5 + Cediranib IC_12.5	0.63	Synergism
	Cediranib IC_37.5 + Selumetinib IC_12.5	0.67	Synergism
	Selumetinib IC_37.5 + Crizotinib IC_12.5	0.70	Synergism
	Cediranib IC_37.5 + Crizotinib IC_12.5	0.79	Synergism
	WP1066 IC_25 +Crizotinib IC₂₅	0.86	Synergism
	WP1066 IC_25 +Cediranib IC₂₅	0.96	Synergism
X1046
	Crizotinib IC_25 +Cediranib IC₂₅	0.08	Synergism
	Cediranib IC_37.5 + Crizotinib IC_12.5	0.09	Synergism
X1016
	Selumetinib IC_37.5 + Cediranib IC_12.5	0.12	Synergism