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. 2018 May 30;8:110. doi: 10.1038/s41398-018-0161-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Top canonical pathways of the predictive genes. Values are expressed as −log (p-value) indicating the significance of the enrichment of the predictive genes in each pathway. b GRM5 encoding metabotropic glutamate receptor 5 (mGluR5) was among the genes with the highest predictive accuracy for fatigue 1-year post EBRT. Genes involved in glutamate signaling were found to be most predictive of fatigue 1-year post radiotherapy. c qRT-PCR validation demonstrating that GRM5 was only detectable in fatigued subjects. ND, not detected. Error bars = s.e.m