Table 1.
Patients’ characteristics
| ALT ≥ 2 × ULN (n = 218) | ALT < 2 × ULN (n = 460) | P value | |
|---|---|---|---|
| Age (median, ≥ 40 years %) | 36, 77 (35.3%) | 38, 205 (44.6%) | 0.024 |
| Gender (male %) | 184 (84.4%) | 345 (75.0%) | 0.006 |
| BMI (median, ≥ 24 kg/m2 %) | 23.3, 76 (34.9%) | 23.0, 165 (35.9%) | 0.864 |
| HBsAg (log10IU/mL) | 3.59 ± 0.77 | 3.56 ± 0.88 | 0.409 |
| AST (U/L) | 116.55 ± 109.99 | 35.50 ± 17.84 | < 0.001 |
| ALP (U/L) | 91.64 ± 29.93 | 77.31 ± 26.07 | < 0.001 |
| GGT (U/L) | 82.62 ± 69.51 | 41.50 ± 47.42 | < 0.001 |
| Albumin (g/L) | 43.67 ± 5.85 | 44.48 ± 5.26 | 0.002 |
| TBil (µmol/L) | 18.30 ± 15.33 | 16.94 ± 22.78 | 0.017 |
| PT (s) | 12.94 ± 1.51 | 12.56 ± 1.49 | 0.001 |
| PLT (× 109/L) | 170.64 ± 52.76 | 172.33 ± 59.08 | 0.635 |
| Hyaluronic acid (ug/L) | 149.05 ± 102.82 | 115.26 ± 71.14 | < 0.001 |
| Laminin (ug/L) | 179.54 ± 302.39 | 84.24 ± 177.79 | < 0.001 |
| PIIINP (ug/L) | 5.65 ± 11.42 | 3.65 ± 5.04 | < 0.001 |
| Collagen IV (pg/mL) | 1120.00 ± 628.19 | 896.98 ± 540.96 | < 0.001 |
| YKL-40 (log10 pg/mL) | 4.46 ± 0.38 | 4.47 ± 0.38 | 0.718 |
| sCD163(log10 pg/mL) | 6.20 ± 0.36 | 6.01 ± 0.33 | < 0.001 |
| MMP-1 (log10 pg/mL) | 3.47 ± 0.31 | 3.48 ± 0.32 | 0.566 |
| MMP-2 (log10 pg/mL) | 5.28 ± 0.10 | 5.26 ± 0.10 | 0.058 |
| MMP-3 (log10 pg/mL) | 4.17 ± 0.25 | 4.17 ± 0.26 | 0.624 |
| MMP-9 (log10 pg/mL) | 4.85 ± 0.41 | 4.87 ± 0.45 | 0.770 |
| TIMP-1 (log10 pg/mL) | 5.08 ± 0.12 | 5.06 ± 0.13 | 0.018 |
| HBeAg status/HBV DNA(IU/mL) (n %) | 0.020 | ||
| G1 e + , HBV DNA ≥ 2 × 107 | 86 (39.4%) | 128(27.6) | |
| G2 e + , 20,000 ≤ HBV DNA < 2 × 107 | 54 (24.8) | 116 (25.4) | |
| G3 e + , HBV DNA < 20,000 | 9 (4.1) | 25 (5.7) | |
| G4 e − , HBV DNA ≥ 2000 | 59 (27.1) | 152 (32.8) | |
| G5 e − , HBV DNA < 2000 | 10 (4.6) | 39 (8.5) | |
| Fibrosis stages (n %) | 0.312 | ||
| F0–2 | 128 (58.7%) | 291 (63.2%) | |
| F3 | 48 (22.0%) | 85 (18.5%) | |
| F4 | 33 (15.1%) | 68 (14.8%) | |
| F5–6 | 9 (4.1%) | 16 (3.5%) | |
Data presented as mean ± SD or no. (%)
BMI body mass index, HBsAg hepatitis B surface antigen, AST aspartate transaminase, ALP alkaline phosphatase, GGT gamma-glutamyl transpeptidase, TBil total bilirubin, PT prothrombin time, PLT platelet counts, PIIINP N-terminal peptide of type III procollagen, YKL-40 chitinase 3-like-1, sCD163 soluble CD163, MMP matrix metalloproteinase, TIMP-1 tissue inhibitor of metalloproteinase 1, HBeAg hepatitis B e antigen, HBV hepatitis B virus, ULN upper limit of normal