Table 4.

Receiver operating characteristics curve (ROC) analysis of noninvasive models for the diagnosis of significant fibrosis in CHB patients with ALT < 2ULN

	AUROC (95%CI)	Cut-off value	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Training group
YKL-40 model	0.786 (0.726–0.846)	− 0.56	71.74	72.85	61.68	80.88
APRI	0.736 (0.670–0.803)	0.76	42.39	93.38	79.60	72.68
FIB-4	0.735 (0.669–0.801)	1.33	50.00	88.08	71.88	74.30
Forns’ index	0.753 (0.688–0.817)	7.75	56.52	82.78	66.66	75.76
Hui model	0.734 (0.667–0.801)	0.12	69.57	70.20	58.72	79.11
Validation group
YKL-40 model	0.831 (0.752–0.910)	− 0.33	71.79	85.33	71.79	85.33
APRI	0.762 (0.668–0.855)	0.50	71.79	73.33	58.33	83.33
FIB-4	0.743 (0.648–0.838)	1.14	79.49	64.00	53.45	85.72
Forns’ index	0.804 (0.723–0.886)	7.12	79.49	73.33	60.78	87.30
Hui model	0.771 (0.684–0.857)	0.08	87.18	54.67	50.00	89.13