Table 5.
Comparison of health-related quality of life (HR-QoL) data assesed by EORTC QLQ-C30 questionnaire in patients treated with (A) partial cystectomy or (B) radical cystectomy (both types of urinary diversion included – ileal conduit and orthotopic ileal neobladder) and in the subroup of radical cystectomy patients treated with (C) ileal conduit or (D) orthotopic ileal neobladder.
| EORTC QLQ-C30 (version 3.0) | A | B | C | D |
|---|---|---|---|---|
| Partial cystectomy Mean ± SD Median (IQR) n = 12 |
Radical cystectomya Mean ± SD Median (IQR) n = 58 |
Ileal conduita Mean ± SD Median (IQR) n = 24 |
Ileal neobladdera Mean ± SD Median (IQR) n = 34 |
|
| Global health status/quality of life scale | 75.0 ± 23.0 | 66.5 ± 23.0 | 58.0 ± 25.3 | 72.3 ± 19.5 |
| 79.2 (52.1–97.9) | 66.7 (50.0–83.3) | 58.3 (33.3–83.3) | 70.8 (56.2–85.4) | |
| n = 57 | n = 23 | n = 34 | ||
| Multi-item function scales | ||||
| Physical functioning | 81.1 ± 10.6 | 75.7 ± 25.5 | 65.8 ± 29.4 | 82.6 ± 19.9 |
| 80.0 (73.3–86.7) | 86.7 (53.3–100.0) | 70.0 (33.3–93.3) | 93.3 (71.6–100.0) | |
| Role functioning | 68.1 ± 29.7 | 71.0 ± 29.2 | 63.8 ± 31.1 | 76.0 ± 27.9 |
| 66.7 (37.5–100.0) | 75.0 (50.0–100.0) | 66.7 (33.3–100.0) | 83.3 (50.0–100.0) | |
| Emotional functioning | 61.1 ± 30.4 | 77.4 ± 22.6 | 72.2 ± 22.3 | 81.1 ± 22.3 |
| 70.8 (33.3–83.3) | 83.3 (58.3–100.0) | 70.8 (52.1–91.7) | 87.5 (66.7–100.0) | |
| Cognitive functioning | 86.1 ± 26.4 | 81.0 ± 21.5 | 77.8 ± 22.9 | 83.3 ± 20.5 |
| 100.0 (83.3–100.0) | 83.3 (66.7–100.0) | 83.3 (54.2–100.0) | 83.3 (66.7–100.0) | |
| Social functioning | 80.6 ± 26.4 | 68.1 ± 32.5 | 65.3 ± 32.2 | 70.1 ± 33.0 |
| 100.0 (66.7–100.0) | 83.3 (33.3–100.0) | 83.3 (33.3–95.8) | 75.0 (45.8–100.0) | |
| Multi-item symptom scales | ||||
| Fatigue | 20.4 ± 17.6 | 30.8 ± 28.5 | 37.5 ± 28.1 | 26.0 ± 28.3 |
| 22.2 (0.0–33.3) | 33.3 (0.0–55.6) | 33.3 (11.1–63.9) | 16.7 (0.0–55.6) | |
| Nausea and vomiting | 8.3 ± 20.7 | 6.0 ± 16.4 | 9.7 ± 20.2 | 3.4 ± 12.8 |
| 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.0 (0.0–12.5) | 0.0 (0.0–0.0) | |
| Pain | 13.9 ± 21.1 | 21.8 ± 33.1 | 26.4 ± 31.8 | 18.6 ± 34.0 |
| 0.0 (0.0–33.3) | 0.0 (0.0–33.3) | 8.3 (0.0–50.0) | 0.0 (0.0–33.3) | |
| Single-item symptom scales | ||||
| Dyspnoea | 13.9 ± 22.3 | 31.6 ± 36.6 | 37.5 ± 35.9 | 27.5 ± 37.1 |
| 0.0 (0.0–33.3) | 33.3 (0.0–66.7) | 33.0 (0.0–66.7) | 0.0 (0.0–41.7) | |
| Insomnia | 33.3 ± 40.2 | 24.7 ± 29.0 | 29.2 ± 31.6 | 21.6 ± 27.1 |
| 16.7 (0.0–66.7) | 16.7 (0.0–33.3) | 33.3 (0.0–66.7) | 0.0 (0.0–33.3) | |
| Appetite loss | 5.6 ± 19.5 | 11.5 ± 24.6 | 18.1 ± 31.1 | 6.9 ± 17.9 |
| 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.0 (0.0–33.3) | 0.0 (0.0–0.0) | |
| Constipation | 8.3 ± 20.7 | 16.9 ± 25.2 | 22.2 ± 30.6 | 11.8 ± 19.9 |
| 0.0 (0.0–0.0) | 0.0 (0.0–33.3) | 0.0 (0.0–33.3) | 0.0 (0.0–33.3) | |
| Diarrhoea | 2.8 ± 9.6 | 15.5 ± 27.4 | 4.2 ± 14.9 | 23.5 ± 31.3 |
| 0.0 (0.0–0.0) | 0.0 (0.0–33.3) | 0.0 (0.0–0.0) | 0.0 (0.0–33.3) | |
| Financial difficulties | 2.8 ± 9.6 | 22.4 ± 33.9 | 25.0 ± 35.8 | 20.6 ± 32.8 |
| 0.0 (0.0–0.0) | 0.0 (0.0–66.7) | 0.0 (0.0–66.7) | 0.0 (0.0–41.7) | |
Continuous data are shown as mean with standard deviation (SD) and as median with interquartile range (IQR).
EORTC QLQ-C30: the questionnaire assesses cancer-specific quality-of live data. In all questions a scale from 1 to 4 was used (1: not at all, 2: a little, 3: quite a bit, 4: very much). All scales were linearly transformed such that all scales range from 0 to 100. For functional and overall scales higher scores represent a better outcome on quality of life (QoL), whereas for symptom and single-item scales higher scores correspond to more problems and a reduced QoL.
aData previously published by Erber et al. Morbidity and Quality of Life in Bladder Cancer Patients following Cystectomy and Urinary Diversion: A Single-Institution Comparison of Ileal Conduit versus Orthotopic Neobladder, Urol 2012;2012:342796.