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. 2018 May 30;8:8427. doi: 10.1038/s41598-018-26457-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Signal-to-noise ratios (SNRs). (a) Example of SNRs vs. number of trials (repetitions of stimuli) for the ED (green), EV (purple), and SD (orange) 750 µm diameter electrodes. Example traces were taken from electrodes closest to each other as determined on an x-ray image. Shaded areas indicate standard error of the mean. The lines are straight line fits (y = P*x + Q) for each array, where x is the number of trials, P is the slope of fit line, and Q is the intercept. (b) Single trial SNR. (c) SNR averaged over 10 trials. (d) The slopes ‘P’ of the fit lines shown in (a). Symbols show individual values, centre lines show mean values, error bars show standard error of the mean. Mood median test showed no significant effect of electrode size or location on either; (b) single trial SNR, (c) Trial averaged SNR or (d) the slope of fit line (p > 0.05).