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. 2018 May 30;8:8383. doi: 10.1038/s41598-018-26560-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of anti-CLDN-5 ECR mAbs on the paracellular barrier of CLDN-5–expressing cells monolayer. Monolayers of MDCKII expressing mock (upper left), human CLDN-5 (upper right) or mouse CLDN-5 (lower left) were basolaterally treated with vehicle (PBS) or 135 µg/mL of antibodies (mouse IgG, 4F1 or 2B12) for 9 h. TEER was monitored throughout the treatment period. Relative TEER (%) to the value at 0 h is shown. Error bars represent standard error of the mean values (n = 3). *P < 0.05 versus vehicle treatment.