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Summary of monoclonal anti-CLDN-5 ECR mAbs obtained in this study.
| Clone | Immunizing antigen | Subtype | Binding specificity | |||
|---|---|---|---|---|---|---|
| hCLDN-5 | mCLDN-5 | Other hCLDNs | Denatured hCLDN-5 | |||
| 1B3 | Antigen1 | IgG1/λ | +++ | − | − | + |
| 4F1 | Antigen1 | IgM/κ | +++ | +++ | − | − |
| 1D1 | Antigen2 | IgG2a/κ | +++ | − | − | + |
| 2B1 | Antigen2 | IgG2a/κ | +++ | − | − | + |
| 2B12 | Antigen2 | IgG2a/κ | +++ | − | − | +++ |
