Table 3.
Logistic regression analysis for association of leukocyte telomere length with albuminuria progression
| Variables | Model 1 OR (95%CI) |
Model 2 OR (95%CI) |
Model 3 OR (95%CI) |
Model 4 OR (95%CI) |
|---|---|---|---|---|
| LTL Quartile 1 | 2.10 (1.15–3.83) | 2.12 (1.15–3.89) | 1.93 (1.04–3.60) | 1.90 (1.02–3.54) |
| Quartile 2 | 1.64 (0.89–3.02) | 1.62 (0.87–3.00) | 1.52 (0.81–2.86) | 1.50 (0.80–2.85) |
| Quartile 3 | 1.81 (1.00–3.26) | 1.73 (0.95–3.15) | 1.61 (0.87–2.95) | 1.56 (0.85–2.88) |
| Quartile 4 | - | - | - | - |
| Age (yr) | 1.00 (0.98–1.02) | 1.00 (0.97–1.02) | 0.98 (0.95–1.01) | 0.98 (0.95–1.01) |
| Female | 1.13 (0.76–1.69) | 1.03 (0.68–1.56) | 1.25 (0.80–1.97) | 1.26 (0.80–1.98) |
| Malea | - | - | - | - |
| Malay | 1.82 (1.11–2.97) | 1.61 (0.97–2.68) | 1.37 (0.81–2.30) | 1.34 (0.79–2.26) |
| Indian | 0.79 (0.47–1.33) | 0.77 (0.45–1.31) | 0.76 (0.45- 1.31) | 0.75 (0.44–1.29) |
| Chinesea | - | - | - | - |
| HbA1c (%) | 0.98 (0.82–1.16) | 0.95 (0.80–1.14) | 0.94 (0.78–1.13) | 0.94 (0.78–1.13) |
| Diabetes duration (yr) | 1.03 (1.01–1.06) | 1.03 (1.01–1.06) | 1.03 (1.00–1.05) | 1.02 (1.00–1.05) |
| BMI (kg/m2) | 1.06 (1.02–1.10) | 1.04 (1.00–1.09) | 1.04 (1.00–1.09) | |
| SBP (mm Hg) | 1.01 (1.00–1.03) | 1.01 (0.99–1.02) | 1.01 (0.99–1.02) | |
| Triglycerides (mM)b | 1.06 (0.67–1.68) | 0.93 (0.58–1.47) | 0.93 (0.58–1.50) | |
| uACR (μg/mg)b | 1.31 (1.12–1.52) | 1.31 (1.11–1.53) | ||
| eGFR (ml/min per 1.73 m2) | 0.99 (0.97–1.00) | 0.99 (0.97–1.00) | ||
| RAS antagonistsc | 0.97 (0.62–1.52) | |||
| Statinc | 1.29 (0.71–2.33) |
Data are ORs (95% CIs) estimated for continuous and categorical variables in different models. LTL was divided into quartiles and quartile 4 (longest LTL) was used as reference. Bold values represent statistically significant data (P < 0.05).
BMI, body mass index; CI, confidence interval; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; LTL, leukocyte telomere length; OR, odds ratio; RAS, renin-angiotensin system; SBP, systolic blood pressure; uACR, urine albumin creatinine ratio.
Male gender and Chinese ethnicity were references (dashes).
Natural log transformed value was used for analysis.
No usage of medicine was reference.