Table 1.
Baseline data of participating kidney transplantation candidates by gender
| Variable | Men (n = 102) | Premenopausal women (n = 16) | Postmenopausal women (n = 28) |
|---|---|---|---|
| Age, yr | 54 (11) | 42 (6) | 60 (7) |
| Body mass index, kg/m2 | 25.7 (3.7) | 25.4 (7.7) | 25.9 (3.7) |
| Active smoker | 34 (33%) | 5 (31%) | 6 (21%) |
| Diabetes mellitus type 1 | 24 (24%) | 7 (44%) | 2 (7%) |
| Diabetes mellitus type 2 | 11 (11%) | 1 (6%) | 1 (4%) |
| Maintenance dialysis therapy | 36 (35%) | 8 (50%) | 9 (32%) |
| Previous kidney transplantation | 14 (14%) | 5 (31%) | 5 (18%) |
| Medical treatment | |||
| Previous steroid exposure | 16 (16%) | 1 (6%) | 5 (18%) |
| Current steroid treatment | 8 (8%) | 4 (25%) | 6 (21%) |
| Phosphate binder | 74 (73%) | 13 (81%) | 16 (57%) |
| Active vitamin D receptor activator | 75 (74%) | 10 (63%) | 20 (77%) |
| Calcium metabolism | |||
| Parathyroid hormone, ρmol/l | 21.5 [14.5, 29.3] | 16.9 [11.9, 27.0] | 19.8 [11.4, 31.4] |
| Phosphate, mmol/l | 1.59 (0.37) | 1.59 (0.44) | 1.48 (0.36) |
| Ionized calcium, mmol/l | 1.22 (0.08) | 1.24 (0.09) | 1.23 (0.06) |
| Bone specific alkaline phosphatase, μ/l | 25 [20−32] | 30 [25–41] | 24 [22–37] |
| Pro-collagen type I N-terminal propeptide, μg/l | 61.0 [40.5–85.3] | 78.1 [37.4–107] | 77.8 [44.9–113] |
| Tartrate resistant alkaline phosphatase type 5b, U/l | 4.1 [2.7–5.8] | 3.5 [2.1–5.2] | 5.0 [3.2–6.3] |
| Sex hormones | |||
| Total testosterone, nmol/l | 13 [10–17] | 0.5 [0.3–0.7] | 0.58 [0.16–0.95] |
| Bioavailable testosterone, nmol/l | 5.71 (2.14) | 0.130 [0.074–0.176] | 0.124 [0.030–0.246] |
| Total estradiol, nmol/l | 114 (42) | 300 [174–692] | 16 [13–47] |
| Bioavailable estradiol, ρmol/l | 74 (33) | 167 [96–270] | 8.3 [5.8–19.8] |
| Sex hormone–binding globulin, nmol/l | 35 [26–48] | 61 [48–81] | 59 [40–84] |
| Bone mineral density | |||
| Lumbar spine vBMD, mg/cm3 | 116 (35) | 167 (30) | 116 (42) |
| Lumbar spine z score | –0.81 (1.20) | 0.42 (1.20) | 0.24 (1.56) |
| Total hip vBMD, mg/cm3 | 227 (41) | 250 (66) | 225 (37) |
| Total hip z scores | –1.11 (1.08) | –1.81 (1.34) | –1.42 (0.66) |
| Femoral neck vBMD, mg/cm3 | 228 (46) | 261 (73) | 233 (48) |
| Femoral neck z score | –0.96 (0.92) | –1.45 (1.17) | –1.26 (0.80) |
| Femoral neck aBMD, mg/cm2 | 0.593 (0.093) | 0.593 (0.143) | 0.541 (0.100) |
aBMD, areal bone mineral density; vBMD, volumetric bone mineral density.
Data are mean (SD), median [interquartile range], or n (%).